Pancreatic cancer causes severe abdominal pain, which can be relieved by a celiac plexus block. The celiac plexus nerves in the abdomen stop providing pain signals to the brain due to this sort of nerve damage. Some types of celiac plexus block relieve pain temporarily, while others provide long-term relief. Pancreatic cancer is a type of cancer that causes considerable pain in 50 to 70% of patients and is notoriously difficult to cure.